Eleven individuals who received the AstraZeneca-Oxford COVID-19 vaccine have developed a rare neurological disorder called Guillain-Barre syndrome, clinicians in India and England have reported in two separate studies.
Seven cases were reported from a regional medical centre in Kerala, India, where approximately 1.2 million people were vaccinated with the AstraZeneca COVID-19 vaccine till April 22. The cases occurred within two weeks of the first dose of vaccination.
“Six out of the seven patients progressed to areflexic quadriplegia and required mechanical ventilatory support,” said Boby Varkey Maramattom, from the Department of Neurology, Aster Medcity, Kochi, Kerala.
Four cases were reported from Nottingham, England, in which approximately 700,000 people received the same vaccine. These were characterised by bifacial weakness with a paraesthesias variant of GBS occurring within three weeks of vaccination with the Oxford-AstraZeneca SARS-CoV-2 vaccine.
“This rare neurological syndrome has previously been reported in association with SARS-CoV-2 infection itself. Our cases were given either intravenous immunoglobulin, oral steroids, or no treatment,” said Jonathan Rhys Evans, Department of Neurology, Nottingham University Hospitals NHS Trust, UK.
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